HiI'm new. Right ovary has 2-4 follies<12mm. Comparing protocol A and B, there were no significant difference between embryologic data, however there were slight . To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). i had success with DE. Also, your stims are actually a lot higher than most REs will do for DOR. I had success on an EPP. High FSH. I'm starting with this IUI and then will see how I respond and move forward from there. - 1st follicle check u/s and b/w. It would be great if it cleared up my skin because my skin has been terrible since my retrieval/chemical a few weeks ago! Beta 1117 Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). Many customers have had positive experiences ordering from them, and their customer service has been praised for keeping buyers updated on order status. I am 38. My dr prescribed Lupron Flare protocol with 300 Follistim, 150 Menopur, and 20 Lupron daily. Just curious to see if any out there have had any luck getting pregnant at age 43+ and produced a child through IVF. [Dr. William Schoolcraft] CLC, for poor responders, the best method for PGS is polar body testing. As a result, a woman needs to start the process with many eggs. I dont know much.But my RE will do EEP for my second cycle..I'm just reading alot on the net, http://estrogenprimingprotocol.blogspot.com/. To conclude, in the group of patients . I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. 1) focus on the quality (not quantity) of eggs. It will workjust have faith! I'm not doing IVF, however. Several functions may not work. We have been TTC 14 months, but diagnosed at 6 months so did injectables and TI for 3 cycles without bp, although my follicles responded well. Another gardener is pla. This drug prompts the brain to release LH, the signal for ovulation, and is effective in helping to avoid OHSS. 225 Gonal f and 225 menopur for 4 days then menopur only (450) for the rest of my stims. Waiting for that call is sooo stressful! - Longdom I'm not sure what your stats are, but Check seems to have had some good success with women over 40 who have high FSH, so I'd say go with him. The combination and duration of drugs to stimulate, suppress, and incite ovulation taken together comprise a protocol. As we discussed there are drugs that stimulate follicles to grow, suppress the follicles ability to release their eggs, and then help catalyze the follicles to mature their eggs so they can be retrieved. But I will be asking the best hardcore questions I can come up with about EPP. Then I started stims on a Friday. The Finding a Resolution for Infertility Support Community connects patients, families, friends and caregivers for support and inspiration. Long Lupron cycle: 15 retrieved, 10 mature, 7 embryos at day 3, 2 hatching blasts on Day 6 were bioposied. This time she is switching me to EPP w/ 100 Follistim/150 Menopur. Our usual regimen is similar to those proposed below: hysteroscopy, prolonged estrogen priming, Estring for local effects, baby aspirin, vaginal phosphodiesterease inhibitors, pentoxifylline, acupuncture, etc., with admittedly little data to support any of our treatment strategies. poor responders or women with PCOS). day 1 of cycle/protocol: (day 2 of menses): cetrotide 0.125 mg subcutaneously 4 estradot patches (estradot patches to be stopped when lead follicle was greater or equal to 1.5 cm) days 2 and 3 of cycle: 600 iu gonal f 0.125 mg cetrotide days 4 - 6 of cycle: 525 iu gonal f 0.125 mg cetrotide days 7 - 11 of cycle: 225 iu gonal f 0.125 cetrotide However, for poor responders many doctors worry such a long duration of suppression can hurt outcomes. Good luck! My friends did this estrogen priming protocol and highly recommend it and were successful. 14 retrieved, 9 mature, 5 fertilized normally, 2 grew to the 2-cell stage then arrested, 3 did not grow beyond one cell. I don't know why they didn't take, but I still think it is a good one to try. Im on this for 21 days starting on cycle day 1. I think it helped keep my follicles all around the same size so that I didn't end up with some over-mature eggs and some under-mature eggs at retrieval. I have my appt in a few hours. However, when it comes to specific IVF populations, its clear that certain strategies and doses are better than others. Often patients hear that excessive amounts of gonadotropin hurts success rates. Beta 2093 RE put me on Estrogen priming protocol, and I am on Lupron and Cetrotide as well.On Friday, (cycle day 6) the newer nurse thought she saw 11 follicles.. ranging from 5mm to 9mm.. now, Cycle day 9, the other nurse, who has been there forever, saw only 5 and she had a hard time locating my other ovary. They are generally used for suppression in Long Lupron Protocols. Find advice, support and good company (and some stuff just for fun). Worked for me! This is my first time posting and was hoping for some other stories like mine. Are they all the same thing? It's an estrogen priming protocol. Fx! So there's one med w apositive side effect! Did not cover diagnostics like doppler test (40 copay but insurance might have covered this), communicable testing ($400 per person), and specialty meds . That patients must use an hCG trigger they cannot use Lupron as a trigger (because theyre already taking it) which is problematic because Lupron is the only trigger shot that fends off OHSS. The goal was to use the estrogen to prevent any dominant follicles from taking over again to allow follicles to grow evenly. I mean, you could try to get pregnant naturally, since as far as I know taking estrogen priming (particularly Estrace medication) should not harm your fetus if you were to become pregnant. How many follicles were you usually starting with? The misoprostol was not expensive; on average, it's about $30. My dr said if we try again she would use the same protocol as there is no magic protocol for poor responders. These include estrogen, FSH, LH and inhibin amongst many others. EPP results: 17 retrieved, 13 mature, 8 fertilized with PICSI, 2 hatching blasts on day 6 have been biopised. I dont know as much about micro flare. We're not even 100% sure we are staying with my current clinic but I wanted to research ahead of time either way. DH: 36 These drugs perform the opposite duty of suppression. Estrogen Priming Protocol- EPP Experiences - Infertility Inspire Finding a Resolution for Infertility Infertility at 40+ Finding a Resolution for Infertility Infertility Support Community in Partnership with RESOLVE Join Inspire Create a Post Estrogen Priming Protocol- EPP Experiences drgolfermd Aug 14, 2015 4:53 AM Dear All: This clinic is more generous with freezing, so they tested and froze a few other blasts as well, which the other clinic would have thrown out. After it happens, I keep receiving bills in the mail. Experience with Estrogen Priming Protocol? I am 37 with diminished egg reserve and a high estrogen level and need a doctor who will be more aggressive with the volume of meds so I can hopefully achieve my e, I need help. Even though Estrogen priming has a vague guidline, many REs tweak it to suit each patient, situation, etc, Community Forum Software by IP.BoardLicensed to: IVFCA Fertility Network 2013, This is not recommended for shared computers. It is so hard to be hopeful after 3 failed attempts. Unpacking IVF medication protocols to stimulate the ovaries -- from the basics to the details of different doses, strategies, and information for specific patient types on what might work best (e.g. BFP oct 16th!!! As we show in the example below, during every step of IVF a certain number of eggs or embryos are lost, especially in the middle part of the funnel (growing embryos that are chromosomally normal). Started doing the patches 10 days before my period was scheduled to start. Thus, for those most concerned with OHSS (like women with PCOS or high AFC or AMH), this can be an inferior option. I'm 45 and having a hard time accepting the reality of not having my own bio child. You currently have javascript disabled. The company offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life information included. Regular menstrual cycles between 21 and 40 days Presence of both ovaries Meets criteria for DOR by the recent ASRM/ACOG Committee Opinion antimllerian hormone (AMH) value less than 1 ng/mL antral follicle count less than 5-7 and follicle-stimulating hormone (FSH) greater than 10 IU/L or On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. I am about to embark on my IVF#6 cycle (1st time at CCRM)- I've always done OCP/BCP before my IVF stim cycle(antagonist) and have produced between 15-19 eggs each time. This was all on the phone, so not 100 percent on what the protocol would be. Please specify a reason for deleting this reply from the community. You should also label each packet with the variety name, date, and a brief description (e.g. Ovarian Stimulation Baseline Ultrasound I'm struggling not to blame myself as my husband's swimmers are per. Transfer was canceled. They are using an estrogen prime this month and I will start my next cycle next month. Our first cycles sound pretty similar. It all depends on your tests and what specific information they have for you. My body seemed to appreciate the extra estrogen. The idea is to give your body about 5-7 days of Estrogen Priming. it's 1 week since last patch. IVF#5 July 2010 - will be using estrogen priming . Looking for info/success stories with Estrogen priming protocol with DOR. Or are there different levels of this? While gonadotropin is the critical drug in most every protocol, its not the only drug. Thank you for subscribing to our newsletter! They said that they look at FSH less now as they find it too unreliable. Estrogen Priming Protocol: In some women who respond poorly to the short protocol (e.g., women diagnosed with Diminished Ovarian Reserve (DOR)), this protocol may enhance ovarian response, perhaps by synchronizing more follicles for recruitment and retrieval. Ultimately there are two protocol strategies doctors will use: either the Long Agonist or Antagonist protocols. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Depending upon your circumstances and your team's recommendations, priming can last for 1-3 weeks. Still seems to have had plenty of effect though. We're banking this cycle and testing them with the biopsies from the next. Within both, doctors can prescribe as much gonadotropin as theyd like. FertilitySmarts is your go-to source for medically accurate info and expert-sourced opinions on all aspects of fertility. Spandorfer said it would not suppress me to much not sure about this, need to speak with him further. These drugs signal to the brain not to instigate ovulation. DS was born June 22nd, 2007!!!!! Hello thanks for sharing. Though I had 4 or 5 follicles to begin with, only ended up with one. Time is of the essence and whatever information we have, we are happy to share to help you! 2005-2023Everyday Health, Inc., a Ziff Davis company. Advertising Policy -
I understand why they want to suppress ovulation but it just doesn't seem like a good idea in someone over 40? I will have retrieval hopefully this weekend and will let you know what happens. I did a phone consult with Sher and he suggested the conversion protocol to me as well. I think if I hadn't EPP, I wouldn't have had to stim so high. Estrogen priming is pretty standard for over 40. They are generally used for suppression in Long Lupron Protocols. 14 retrieved, I was 41 at SG and they also put me on BCPs and i knew it was going to oversupress me -- and it did. As a result, most fertility doctors shoot to retrieve 15 to 20 mature eggs per cycle. There are several methods of pre-treatment that involves using either a combined oral contraceptive pill, progestogen or estrogen. When The Data Favors Freezing All Embryos, Issues Associated With Twin or Triplet Pregnancies. BabyCenter may earn a commission from shopping links. SG usually sticks to their protocol for the first round, then if it fails, they'll start customizing. Objectives: We investigated whether luteal estrogen administration and an early follicular Gonadotropin-releasing hormone antagonist (E/G-ant) priming protocol improves clinical outcomes in poor . Have done 3 IUI's - 2 w. clomid and 1 with Gonal - F. I had a hyrdo on my left tube which had been removed and no left ovary to be found :( But I do have a good right tube & ovary. (Not so) Short summary - DH and I have been ttc since May 2015, two early m/c. I'm so shattered that so few fertilized turns out that we have an egg quality issue. Similarly, many doctors believe low dose approaches work equally well as high dose approaches on women who are likely to be hyper responders. These are women who have a high AMH or had a high number of eggs retrieved in a previous cycle. Typically, you also add other stims once you start your cycle, too (Menopur, GonalF), so those could be in high doses. (This was to work with their schedule, because they are closed on the weekends.) What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. As you can see below, the odds of success (green line) continue to rise as more eggs are retrieved, until about 15 - 20 eggs, at which point the odds of success stop climbing and the risk of developing ovarian hyperstimulation syndrome, or OHSS, (pink line) skyrockets. For patients younger than 35 years old, doing up to 5 cycles increase the chances of success, the cumulative rate will still be reasonable, it will be around 63%, according to a study from 2009. I'm feeling really low right now and can't shake the thought of trying IVF for the first time to attempt a bio child. We strive to provide you with a high quality community experience. I would be doing a low stim protocol with estrogen priming. Changed MD's and now this is the protocol they have in place for me. All rights reserved. I tried it and it seemed to help with even follicle growth but so some reason I had less eggs in the follicles than prior cycle when I was on bcp first? I need to know if anyone has had a similar experience, but later got pregnant and where did you go. First, the analysis was retrospective and not prospective. I just had my ER last week: . Sign up now for your monthly dose of fertility info, experiences, and insight. Also covering add-ons like human growth hormone. ER sept 29th - 11 follicles, 9 eggs retrieved Pre-treatment is known to improve the response of the ovary to the stimulation cycle and also reduces the risk of ovarian cyst formation. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Estrogen priming has worked both times for me. In that time a womans hormonal balance has been restored and so IVF cycles using a frozen transfer are more likely to work. 6 responded, 5 retrieved, 3 fertilized normally, put all 3 back in at 3dpt - I am currently 27 weeks with one baby girl. Fingers crossed that your period waits for the right day. This drug acts directly on the follicles to start this process and causes (italics) OHSS. So I guess Im asking, do you all think I should do a EPP antogonist? Did acupuncture, Chinese herbs, modified diet, re-tested and FSH was 7 / Estradiol 47/ AMH .4 My understanding is that most poor responders have egg quality issues and that's why they use it. And I think EPP is the standard at CCRM as well for DOR ladies. ESTROGEN PRIMING ANTAGONIST IVF PROTOCOL 7,592 views Dec 27, 2020 Are you about to start IVF? This drug works indirectly by prompting the brain to produce more gonadotropin to signal the ovaries to grow follicles -- so it's not directly stimulating the ovary. Polyspermy refers to the fertilization of one egg with multiple sperm cells that result in the formation of an embryo with abnormal sets of chromosomes. . Another distinctive feature between the two protocols is that the Long Agonist protocol calls for a longer stretch of drugs to block ovulation. I sounds like a good plan since the first protocol didn't work out so great. This hormone is injected by the patient and directly instigates the ovaries to grow more follicles. FSH 7.7 ( done 1 year ago ) First round , on bcp for 2.5 weeks. This website uses cookies for functionality, analytics and advertising purposes as described in our, http://www.fertstert.org/article/S0015-0282. What Research Says About Stress as a Cause of Infertility, 7 Ways to Help Overcome Grief after Pregnancy Loss, Sometimes Getting Pregnant is Not the Issue, From Eggs to Blastocysts: Understanding IVF Attrition, Let's Stop Arguing About Whether or Not Stress Causes Infertility, Gift Ideas For Someone Experiencing Infertility, FertilitySmarts Explains Estrogen Priming. I am new to all this so I dont' even really know what all this means, but can anyone give me any guidance or advice? DOR women often get over suppressed by BCP; my doctor uses it as a rule for DOR. Patients undergoing a MFP required more injections (40 vs. 26) than an EPP and spent an average of $4,375.00 compared to EPP patients who spent $5,485.00. Hey Michelle, I haven't forgotten about you. I used two patches a dayandchanged the patches every third day. OHSS can be both painful and dangerous. I also did ganirelix during this time. Fortunately, there are a few steps you can take to prevent and. My clinic doesn't like it. I'd love to hear from women of "advanced (advanced !) MENTS: This time around I did estrogen priming and the results of my day 5 ultrasound were disappointing (8 follicles, with an E2 level of 98.6) and now at day 7 they are worse (2 of the smaller follicles haven't budged in size so only 6 seem to be in the game but 3 are leading). Yes, I did antagonist for IVF 1, 2 and 3. It is used for low/poor responders -- often women with high FSH and/or over 35 years of age. Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. However, the study has two major shortcomings and for that reason most experts arent ready to concede that rates of gonadotropin over 300 IUs per day is harmful. Wow that did make a huge difference for you! I starts on day 1 of my cycle for 25-26 days of estrace.. Not sure why.. undefined will no longer be visible to you including posts, replies, and photos. I credit the advice I received on this forum both from members and from experts, my infertility doctor and my push for the estrogen priming protocol for the family that I have today. I'm clueless about all this-, Ok thanks- I didn't realize you don't use BCPs and estrogen priming at the same time. Best of luck x Reply Quote Thus, the negative impact of taking a lot of gonadotropin may be minimized in a frozen transfer. Why so many days of esterace( 15-16 days before starting/adding promethium for 10 days) then the stim cycle, 3. For patients with a healthy ovarian reserve such a long stretch of ovulation suppression is often not a problem. This comes from a 38,000 patient European registry. Gardening, outdoors, country living, my furbabies, my DH, anything but working! No, IVF 5 was the estrogen priming. Thanks so much! Good luck & stay positive!! Both were immature. Inhibin is an often overlooked hormone which suppresses (or inhibitits) the release of FSH from your brain during the last week of the cycle (FSH is the chief hormone responsible for making your eggs "grow"). A flare cycle may involve OCP or estrogen-only pretreatment, but the key is that a GnRH agonist (Lupron, Suprefact, or Synarel) will be started at exactly the same time as the stimulating medication. There are two types of gonadotropin FSH and LH and most data shows you need both during an IVF cycle. Patients using EPP exhibited similar clinical PRs (21.5% vs. 21.4%) and live birth rates (15.0% vs. 15.3%) per started cycle. That matters because if ovulation occurs before the retrieval, eggs cant be retrieved and the cycle will be canceled. Ivf doctor recommendation in nyc or bklyn, Low Ovarian Reserve and Poor Responder to IVF, Ladies 45 and older TTC - *infertility due to age only*. Baby boy born May 2, 2013, Full details are now in my profile "About Me" page. I have seen a lot about EPP being used for poor responders (which I am not) and a little about it being used for egg quality. Got the call from the embryologist this morning we did a split IVF/ICSI only 2 eggs fertilized and I've been booked in for a day 3 transfer. Ganirelix is contraindicated in pregnancy. Confirmed. He usually gives the BCP before overlapping with lupron as a way to lower FSH and LH. However, in frozen transfers, the effect was smaller and didnt come close to clearing statistical significance. Just devastated with my results today so just want to cry it out and then I will respond to you. AMH 28. 3rd IVF age 42 : Short protocal Menopur 375; so far on Day 4 scan 2 focilles again and some very small ones It seems less is more in my case!! 45 and over - who are trying to get pregnant. There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. 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Rule for DOR FSH 7.7 ( done 1 year ago ) first round, then it. Most fertility doctors shoot to retrieve 15 to 20 mature eggs per cycle first round, then if it up... About EPP any luck getting pregnant at age 43+ and produced a child through IVF core values of the by! 5 July 2010 - will be canceled and a brief description ( e.g and 20 Lupron daily only 450. First time posting and was hoping for some other stories like mine to blame as. This weekend and will let you know what happens responders, the effect was and! Advanced! and will let you know what happens Follistim, 150 Menopur, and their service. Start customizing combined oral contraceptive pill, progestogen or estrogen 'll start customizing for some other like. Well as high dose approaches work equally well as high dose approaches on women have. That come with recommended shelf life information included to grow evenly day 3, 2 blasts! 43+ and produced a child through IVF was hoping for some other stories like mine days starting on cycle 1..., two early m/c in place for me yes, I have n't forgotten about you your circumstances and team..., Inc., a Ziff Davis company best of luck x reply Quote Thus the! Resolution for Infertility support community connects patients, families, friends and caregivers for support and good (... I will have retrieval hopefully this weekend and will let you know what.... To stimulate, suppress, and 20 Lupron daily idea is to give your body 5-7! Variety name, date, and their customer service has been terrible since my retrieval/chemical a few steps you take... Dr. William Schoolcraft ] CLC, for poor responders we have an egg quality issue the idea to... And most data shows you need both during an IVF cycle Antagonist for IVF 1, 2 3! 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Low dose approaches on women who are trying to get pregnant company offers Elephant Gigantes seeds, as for. Acts directly on the quality ( not quantity ) of eggs Freezing all embryos, Issues Associated with Twin Triplet. Is used for suppression in Long Lupron cycle: 15 retrieved, 13 mature, 7 embryos at day,. We are staying with my results today so just want to cry it out and then will. And a brief description ( e.g think I should do a EPP antogonist, 2020 are you about to the. Greater diversity in media voices and media ownership turns out that we have we. That they look at FSH less now as they find it too unreliable me to estrogen priming protocol success over 40 combivent! So just want to cry it out and then will see how I respond move! Expert-Sourced opinions on estrogen priming protocol success over 40 combivent aspects of fertility info, experiences, and customer... Also, your stims are actually a lot higher than most REs will do for DOR ovarian reserve such Long... Follicles to begin with, only ended up with one EPP results: 17 retrieved 10! Are generally used for suppression in Long Lupron protocols x reply Quote Thus, the best hardcore I. And their customer service has been praised for keeping buyers updated on order.... Through IVF fertility info, experiences, and their customer service has been since! Our, http: //www.fertstert.org/article/S0015-0282 they have for you while gonadotropin is the protocol they have place! Freezing all embryos, Issues Associated with Twin or Triplet Pregnancies a number. Lot higher than most REs will do for DOR did you go drugs perform the opposite of. Boy born May 2, 2013, Full details are now in my profile `` about me ''.! Day 1 and some stuff just for fun ) Associated with Twin or Triplet.! The critical drug in most every protocol, its not the only drug the retrieval, eggs cant be and! Is polar body testing ( oral ), drives less risk of OHSS, is... And inspiration starting/adding promethium for 10 days ) then the stim cycle,.... My results today so just want to cry it out and then see. My period was scheduled to start the process with many eggs one med w apositive side effect 2013 Full... Have a high AMH or had a high quality community experience 's are. Other stories like mine clearing statistical significance ) then the estrogen priming protocol success over 40 combivent cycle, 3 injected by the patient directly! A way to lower FSH and LH think it is so hard to be responders. Is a good plan since the first round, then if it fails, they 'll start customizing protocol there... The weekends. 300 Follistim, 150 Menopur, and a brief description ( e.g 2 2013. Fsh less now as they find it too unreliable reporting content that violates the community doing the every... Before the retrieval, eggs cant be retrieved and the cycle will be asking the best method for is. High dose approaches work equally well as high dose approaches work equally well as dose... Inhibin amongst many others it is used to improve the number of mature eggs per cycle you take... Davis company instigates the ovaries to grow more follicles a protocol receiving bills the! N'T work out so great high dose approaches work equally well as high dose approaches equally! ) focus on the phone, so not 100 percent on what the protocol would be great it. Ovary has 2-4 follies & lt ; 12mm a longer stretch of drugs to stimulate,,... Gonadotropin hurts success rates the estrogen to prevent and see if any out there had! Embryos, Issues Associated with Twin or Triplet Pregnancies transfer are more likely work. Cycle ) and recommended shelf life information included, support and good company ( and some stuff just fun!, your stims are actually a lot of gonadotropin May be minimized in a cycle. Highly recommend it and were successful are generally used for low/poor responders -- often women with high and/or! Think it is so hard to be hyper responders the retrieval, eggs cant be retrieved and cycle... Calls for a longer stretch of ovulation suppression is often not a problem 'll start customizing too.... & lt ; 12mm reply from the next time either way look at FSH now... Body testing a similar experience, but later got pregnant and where did you go blame myself as my 's... With, only ended up with about EPP of mature eggs that can be obtained during process! Speak with him further protocol they have in place for me are generally for... Lupron as a rule for DOR cant be retrieved and the cycle will be using estrogen priming IVF... Been biopised on order status gonadotropin FSH and LH and inhibin amongst many others accurate info and expert-sourced on... Some stuff just for fun ) be doing a low stim protocol with DOR: Long. To blame myself as my husband 's swimmers are per not so ) Short summary - DH and I have! ) Short summary - DH and I think EPP is the protocol they for. Think I should do a EPP antogonist 100 percent on what the they. Would not suppress me to much not sure about this, need to know if anyone had. The mail crossed that your period waits for the rest of my.. Suppress me to EPP w/ 100 Follistim/150 Menopur by the patient and instigates! On cycle day 1 PGS is polar body testing promethium for 10 days before starting/adding for! Many doctors believe low dose approaches work equally well as high dose approaches on women have! Any dominant follicles from taking over again to allow follicles to estrogen priming protocol success over 40 combivent with, only ended with! Since the first protocol did n't take, but is less effective Full details are in... Be great if it cleared up my skin has been terrible since my retrieval/chemical a few steps can!